We have now posted several blogs discussing the impact of anti-mullerian hormone (AMH) and fertility. AMH levels predict number of eggs that will be retrieved during in vitro fertilization (IVF) and pregnancy rates. AMH levels vary based on age and we have previously discussed what constitutes a “normal” AMH level. Young patients with low AMH levels will do better than their older counterparts. IVF success rates in patients with low AMH levels have also been discussed previously.
A recent study (Seifer et al. Fertil Steril 2015, In press) analyzes IVF success rates in patients with ultralow AMH levels. They defined ultralow AMH level as < 0.16 ng/ml, the lowest level detectable by a standard clinical AMH assay (Gen II enzyme-linked immunosorbent assay Beckman-Coulter). They retrospectively analyzed data from Society for Assisted Reproductive Technology (SART) clinic outcome reporting system database for 2012 – 2013.
5,087 (7.3% of total cycles) fresh and 243 (1.5%) frozen embryo transfer cycles were analyzed. Comparison was made with age-matched cycles with normal AMH levels (controls).
Here is what they found:
The IVF cycle details were as follows:
Which patients had the greatest chance of success?
These were the patients that had the greatest chance of a successful outcome despite their ultralow AMH levels.
What does all this mean?
Patients with ultralow AMH levels should not be denied access to IVF. They, however, should be counseled about the high cancellation rate and relatively low pregnancy rates with IVF.
To see a fertility specialist who will answer your questions about IVF success rates, make an appointment at one of InVia Fertility’s four Chicagoland locations.
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Dr. Karande is Board Certified in the specialty of Obstetrics and Gynecology as well as the subspecialty of Reproductive Endocrinology and Infertility. He is a Fellow of the American College of Obstetricians and Gynecologists and Member of the American Society for Reproductive Medicine.
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