Management of polycystic ovarian disease (PCO). In obese patients with PCO, diet and exercise remain the mainstay of treatment. Metformin (Glucophage XR) is a pill prescribed to women with insulin resistance and/or PCO. This drug is often used in diabetes, and helps lower levels of insulin. It often helps restore normal menstrual cycles in women who do not normally ovulate. A thorough discussion on PCO is included here.